Clarence was the first town to be established in Erie County, and Buffalo – the county seat, and the second-largest city in New York state – was formed from Clarence. Gypsum mining was done in Clarence in the 20th century. The town gained notoriety in 2009, when Flight 3407 crashed in Clarence Center, killing dozens of passengers and four crew members. The town holds an annual 5K race to commemorate the event.
The Clarence Historical Society Museum is at 10465 Main St. Antique World Market is a sprawling flea market complex that is open year-round. The Asa Ransom House is a circa 1853 bed and breakfast named after Asa Ransom, one of the area’s earliest settlers.